How do memes simplify complex topics, making them politically legible and emotionally digestible to wide and diverse audiences on an increasingly global scale, using the techno-social affordances of social media platforms? This interdisciplinary project seeks to understand how memes are produced and mobilized to communicate ideas, attitudes and affects related to COVID-19 and climate change, as a way of probing larger societal sentiments around these intertwined global crises. It assumes a collaboration between anthropology, political communication science, and media studies, and is funded by the Global Digital Cultures initiative at the University of Amsterdam.